The family dog warns Tom not to make any noise so he can take a nap. Jerry hears this and immediately devises plans to ensure that the dog's nap will be interrupted.
Tom's new book on "how to catch a mouse" doesn't prove too helpful against Jerry; actually, Jerry seems to make better use of it than Tom.
Tom, complete with mortarboard, is teaching a kitten the basics: "cats chase mice." But Jerry keeps subverting this lesson at every opportunity.
A moment after a bottle of white shoe polish pours on Jerry, Tom hears on the radio that a white mouse, having swallowed an explosive, has escaped from an experimental laboratory and that slightest jar of the mouse could cause it to explode and blow up the entire city. It is then that Tom notices now-white Jerry and concludes it's the escapee.
Tom is given the task of guarding the fridge during the night by Mammy-Two-Shoes, but as soon as he has started he is tricked by Jerry into falling into the basement, where he lands in a barrel of cider. Now drunk, Tom staggers around in the house getting up to no good with Jerry.
Jerry finds himself in charge of a foundling mouse called Nibbles, who is eager to steal milk from Tom's bowl and oblivious to the danger.
Jasper is given an ultimatum by his master: break one more thing and you're out. Rodent Jerry does his best to make sure that his tormentor "gets the boot".
Minnie gives Figaro a bath and ties a ribbon around his neck. Figaro feels like a sissy, and when he mixes it up with some alley cats, they mock him, and the leader attacks. But Figaro is so afraid that his shaking topples a series of trash cans onto the aggressor. The rest of the cats didn't see this happen, and think Figaro defeated their leader. Of course, now he's all dirty, and he needs another bath.
Jerry and his diapered little mouse friend flood the kitchen, then use the freezer to turn it into a skating rink. Even though Tom finds a pair of ice skates, the mice have no problem outmaneuvering him.
Tom subjects Jerry to his usual harassment; but the cat finds a new enemy, and the mouse finds a new friend, in the canary of the house.
When a bulldog threatens Tom to keep away from his puppy, Jerry realizes that sticking close to the boy is the best way to keep away his feline tormentor. But Tom is not about to let the mouse evade him so easily.
Tom chases Jerry into a bottle of invisible ink, and the now-invisible Jerry proceeds to have fun torturing Tom.
Jerry removes a tack from Spike's paw. In gratitude, Spike gives Jerry a bell to ring when he's in trouble.
Tom's chasing Jerry when he runs right into a sleeping dog and the two of them must work together to fend him off.
Jerry and his little French mouse friend are raiding while the king sleeps. They awaken him and he calls for Tom to give him an ultimatum: One more sound from the mice and it's off with Tom's head. The mice hear this and team up to torment Tom.
Mammy steps out for the evening. While she's away, the cats - in this case Tom and three of his alley cat friends - play. Play and perform rollicking jazz, that is.
Tom hears a ghost story on the radio and is spooked by it; Jerry notices this and takes advantage of it, using a variety of tricks to scare Tom.
Plankton's tangled love story with his sentient computer wife goes sideways when she takes a stand — and decides to destroy the world without him.
Mammy Two-Shoes threatens to throw Tom out of the house if he makes a mess. Jerry sees an opportunity to rid himself of his feline nemesis.
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